Last News
9 January 2012
The CDC25B phosphatase shortens the G2-phase of neural progenitors and promotes efficient neuron production
Emilie PECO, Timothé ESCUDE, Eric AGIUS, Virginie SABADO, François MEDEVIELLE, Bernard DUCOMMUN, and Fabienne Pituello. Development in press. During embryonic development, changes in cell cycle kinetics have been associated with neurogenesis. This observation suggests that specific cell cycle regulators may be recruited to modify cell cycle dynamics and influence the decision between proliferation and differentiation. In the present study, we investigate the role of core positive cell cycle (...)
8 January 2012
Combinatorial coding of Drosophila muscle shape by Collier and Nautilus
by Jonathan Enriquez, Mathilde de Taffin, Michèle Crozatier, Alain Vincent, and Laurence Dubois. Developmental Biology, in press. The genetic and molecular mechanisms that build up muscle diversity are still poorly understood. Muscle diversity is first revealed by the unique patterns of identity transcription factors that accompany muscle progenitor segregation and specification. J. Enriquez et al. have addressed the question of, when and how, a combinatorial code of identity transcription (...)
14 November 2011
Nouvel article
Marc Moreau et Jacques Haiech (Strasbourg) éditeurs d’un numéro spécial consacré au calcium de la revue Biochimie. (voir http://www.sciencedirect.com/scienc...)
20 October 2011
RNA binding proteins, RNA granules and gametes: Is unity strength?
Changes in mRNA translation and degradation represents post-transcriptional processes operating during gametogenesis and early embryogenesis to ensure regulated protein synthesis. Numerous mRNA binding proteins (RBPs) have been described in multiple animal models that contribute to the control of mRNA translation and decay during oogenesis and spermatogenesis. An emerging view from studies performed in germ cells and somatic cells is that RBPs associate with their target mRNAs in (...)
20 October 2011
The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages
Posttranscriptional mechanisms are crucial to regulate spermatogenesis. Accurate protein synthesis during germ cell development relies on RNA binding proteins that control the storage, stability, and translation of mRNAs in a tightly and temporally regulated manner. Here, we focused on the RNA binding protein Embryonic Lethal Abnormal Vision (ELAV) L1/Human antigen R (HuR) known to be a key regulator of posttranscriptional regulation in somatic cells but the function of which during (...)
Informations
Database
The Drosophila l(1)P Database
Conférence Jacques Monod
"Emergence and Evolution of Developmental Patterns"