Accueil > In the headlines

Ca2+ coding and decoding strategies for the specification of neural and renal precursor cells during development.

par Eric AGIUS - publié le

Marc Moreau, Isabelle Néant, Sarah E. Webb, Andrew L. Miller, Jean-François Riou, and Catherine Leclerc Cell Calcium (Available online 17 December 2015)

During embryogenesis, a rise in intracellular Ca2+ is known to be a widespread trigger for directing stem cells towards a specific tissue fate, but the precise Ca2+ signalling mechanisms involved in achieving these pleiotropic effects are still poorly understood. In this review, we compare the Ca2+ signalling events that appear to be one of the first steps in initiating and regulating both neural determination (neural induction) and kidney development (nephrogenesis). We have highlighted the necessary and sufficient role played by Ca2+ influx and by Ca2+ transients in the determination and differentiation of pools of neural or renal precursors. We have identified new Ca2+ target genes involved in neural induction and we showed that the same Ca2+ early target genes studied are not restricted to neural tissue but are also present in other tissues, principally in the pronephros.
In this review, we also described a mechanism whereby the transcriptional control of gene expression during neurogenesis and nephrogenesis might be directly controlled by Ca2+ signalling. This mechanism involves members of the Kcnip family such that a change in their binding properties to specific DNA sites is a result of Ca2+ binding to EF-hand motifs.
The different functions of Ca2+ signalling during these two events illustrate the versatility of Ca2+ as a second messenger.